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Strong family history of heart disease and stroke

Microglial ferroptosis can activate neurotoxic astrocytes through pro-inflammatory signaling, and ferroptosis-related genes such as ALOX5/15 are highly enriched in microglia, yet this study does not establish whether ferroptosis is upstream in the cascade involving mitochondrial complex IV defects, oxidative stress, and neuroinflammation

Case Rep Neurol Med 2013

Dermatomyositis most commonly occurs in children between 5 and 15 years old, or adults in their late 40s to early 60s