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Modulation of neurotransmission and synaptic plasticity by mGlu receptors is still a potential target for the development of neuroprotective, anti-inflammatory and symptomatic drugs in PD, because these receptors are highly expressed in the basal ganglia motor circuit, and have been implicated in the pathophysiology of motor symptoms, NMS and LIDs (Fig

Some of the research on autism points to imbalanced glutamate and GABA neurotransmission.[ref][ref] One thing to remember here is that GABA is an inhibitory neurotransmitter in the developed brain, but in the fetus or developing infants brain, GABA acts in different ways

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