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2010;16(5):CS58-61

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Metabolism, mainly hypoxic conditions, can drive EMT through NF - B, PI3K/Akt/mTOR, Notch, Wnt/ - catenin , and Hedgehog signaling pathways (Fan et al., 2013)

Three months after hospital discharge, about 30% of COVID-19 patients demonstrate adverse ventricular remodeling, which indicates cardiac sequelae 190,191

11 Further evidence for increased oxidative stress has been demonstrated in the rodent PPA model, including increased brain protein carbonylation and lipid peroxidation, altered phospholipid profiles and increased activated microglia