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Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation

This tissue-level energy crisis is a primary driver of the debilitating post-exertional malaise (PEM) seen in ME/CFS

Among select SERPINA1 variants (protease inhibitor [Pi]*MS, Pi*MZ, Pi*SS, Pi*SZ, Pi*ZZ), the Pi*ZZ genotype carries the highest overall risk of AATD-LD

When acetyl groups break off the fatty acid chains, the acetyl groups then non-enzymatically combine to form ketone bodies, acetoacetic acid, beta-hydroxybutyric acid and acetone, all of which increase the acidity of the blood

The cellular thermal shift assay for evaluating drug target interactions in cells

Ligand-dependent TLR4 activation (e.g., by advanced glycation end-products or LPS), initiates NF-B-driven pro-inflammatory and fibrotic cascades and NLRP3 inflammasome priming