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Dual roles for HMGB1: DNA binding and cytokine

GCH1 is the rate-limiting enzyme for BH4, and the GCH1/BH4 pathway can regulate redox reactions and cell apoptosis, thereby protecting cells from the impact of oxidative stress and mitochondrial damage (83, 84)

De GoffauMCFuentesSvan den BogertBHonkanenHde VosWMWellingGWet al

These changes subsequently inhibit ferroptosis in ovarian granulosa cells, ultimately improving IR and ovarian function, which contributes to its therapeutic efficacy in PCOS ( 5.1.3 Polysaccharide Astragalus polysaccharide (APS) is a water-soluble heteropolysaccharide extracted from the stems or dried roots of Astragalus membranaceus and represents the most abundant and biologically important component of this herb

During seed germination, a delayed degradation of PSVs was also observed in the snx1 mutant and the snx1/snx2a/snx2b triple mutant (Fig