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The Silent Appeal! Booklet appealing for contributions for cigarettes for Belgian soldiers and containing donation coupons issued by The Belgian Soldiers Tobacco Fund and administered by the Over-Seas Club 1917 An Explanation and a Request Postcard from a captain to Mrs

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Further, in vitro cellular studies have shown that constituents of cigarette smoke lead to depletion of the cofactor tetrahydrobiopterin in vascular endothelial cells, which is essential for endothelial NO synthase function, resulting in uncoupling and dysfunction of endothelial NO synthase and endothelial dysfunction ( in vivo studies in smokers and in vitro studies in bovine aortic endothelial cells (Peluffo et al., 2009)