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Since gene therapy is still being investigated in two phase I/II clinical trials (39), liver transplantation is established and would at present serve the same purpose

Lakhani CM, Tierney BT, Manrai AK, Yang J, Visscher PM, Patel CJ

Kumar H, Ha DH, Lee EJ, Park JH, Shim JH, Ahn TK, et al

They were referring to a study by the Federal Drug Authority in USA who looked at the effectiveness of old drugs,, some as old as thirty years and found them still as good as new.The NHS take a different view

Int J Mol Med 57(5):109 Tang SP, Mao XL, Chen YH, Yan LL, Ye LP, Li SW (2022) Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death

Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors