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Treatment : Transfusions: Hb values fall below 7gr / dl Facial deformations Poor growth Bone expansion Increased splenomegaly Treatment of Fe overload Splenectomy Chelation therapy: Administer Iron chelators for elimination in urine and feces (from 10 to 20 transfusions or at ferritin levels above 1000 ng/ml)

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plasma half-life is 2 minutes The principal routes of metabolism are methylation of the catechol and conjugation Drug Interactions: Do not add dobutamine to 5% Sodium Bicarbonate Injection or to any other strongly alkaline solution

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