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The arginine dose is too small to matter pharmacologically

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Some symptoms of GHB withdrawal, such as delirium, is more often encountered after chronic drug use on average every 2-3 hours, with a range of 0.5-8 hours, compared with less intensive usage on average every 7 hours, with a range of 1-24 hours

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The limited availability of betaine may also have resulted in increased conversion of homocysteine to cystathionine instead of it being recycled back to methionine (Supplementary Fig