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20 HAPE, often misdiagnosed as acute pneumonia before 1960, was first reported by Dr Charles Houston 21 and later identified as noncardiogenic pulmonary edema by Hultgren et al

Previous studies have found that ACSL4 catalyzes the activation of AA to AA-CoA, which can be utilized to generate 5-hydroxyeicosatetraenoic acid (5-HETE) by lipoxygenase (LOX), thus inducing ferroptosis via 5-HETE-mediated lipotoxicity [135]

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81,120 Given the fact that poor water solubility and unstability of erastin, a metabolically stable erastin analogue, imidazole ketone erastin (IKE), has been developed

MYB proto-oncogene, transcription factor (MYB)-mediated expression of cysteine dioxygenase type 1 (CDO1), an enzyme that converts cysteine to taurine by catalyzing the oxidation of cysteine to sulfinic acid, can promote erastin-induced death in gastric cancer cells, 89 indicating that non-GSH-dependent cysteine metabolism is also involved in controlling ferroptosis

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