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However, during later stages of the infection cycle, SARS-CoV-2 triggers an ongoing expression and/or activation of the transcription factor nuclear factor kappa light chain enhancer in B-cells (NF-B) and downstream, of tumour necrosis factor (TNF)-, interleukin (IL)-1, IL-6, IL-18 (hereinafter termed pro-inflammatory cytokines) and IFN- (the only type II IFN), with little contribution of antiviral IFN I/III (3, 10)

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These insights not only validate preclinical models but also inform therapeutic strategies targeting shared mechanismssuch as neuroinhibition, oxidative stress, and neurotrophic deficitsto break the cycle of ethanol-induced depression

Because those younger than 65 years of age would not be captured by the ODB database, another cohort was created

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Ethical approval Ethical approval is not required for this study Informed consent Informed consent is not required for this study