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Disclosure of interest: RJvO and WHvZ report financial support for the current manuscript from the Collaboration for New Treatments of Acute Stroke (CONTRAST) consortium (which was financed for the current study by the Netherlands Cardiovascular Research Initiative, an initiative of the Dutch Heart Foundation, the Netherlands Brain Foundation, Stryker, Medtronic, and Cerenovus), all paid to their institution

These short-term complications could be further reduced by the optimisation of patient selection, pre-, and perioperative diagnostics

The size of the needle matters too

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Fortunately, humans need only 2.4 micrograms of B12 daily, which is equivalent to one ten-millionth of an ounce a very, very small amount

Convenience and compliance This is where the ODT wins decisively for some patients