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Concerning Breese McCoys study (130), one comment is the limitation given by the fact that only thyroid function tests were monitored, while thyroid autoantibodies were not

Cheng, H

Pharmacology [edit] Pharmacodynamics [edit] Although the mechanism of action of valproate is not fully understood, [38] traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of the inhibitory synaptic neurotransmitter gamma-aminobutyric acid (GABA)