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The disease can cause ulcerations within the intestine that can erode into surrounding tissues such as the bladder (Sato 1999), vagina (Feller 2001), or even the surface of the skin (Tavarela 2004)

Advances in molecular and structural characterization have elucidated the catalytic architecture and cofactor interactions that underpin their functional diversity

Further, absolute oral in rats, monkeys and dogs was 45%, 7288%, and 86%, respectively

Oral adenine is classified as acutely toxic and is often used to induce chronic kidney disease in rodents, caused by the catabolism of adenine into 2,8-dihydroxyadenine that crystallizes in renal tubules 69

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