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Preclinical data have not shown prominent adverse effects, but human safety data are limited

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When any component fails, oral supplementation becomes far less effective, potentially requiring massive doses to achieve therapeutic blood levels

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At present, scurvy is considered a rare disease in developed countries, but it can occur in vulnerable social environments, in alcohol consumers, and in people with severe psychiatric problems [13,14,15]

[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC