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Impairments in neuronal survival mediated by HMGB1 are believed to be closely associated with the glycolytic pathway, as evidenced by the mitigation of these adverse effects through treatment with the glycolysis inhibitor 2-DG [194]

Fifth, S-adenosylmethionine (SAM), the methyl-donating substrate of histone methyltransferases, and S-adenosylhomocysteine (SAH) link one-carbon metabolism to methylation status

Ji LL, Gomez-Cabrera MC, Steinhafel N, Vina J

Ziebell and Morganti-Kossmann, 2010)

From this, researchers have concluded inhibition of CYP1A activity by cacao products may prevent DNA damage by reducing metabolic activation of carcinogens

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