glutathione peroxidase 5 function Pathways GPX4-independent ferroptosis—a new strategy in

The liberated N-terminal fragment of GSDMD (GSDMD-N) oligomerizes within the plasma membrane to form pores, leading to pyroptotic cell death 52

Similarly, the upregulation of cytokines production in epithelial cells has been shown to be suppressed by sulforaphane, including in Caco-2 [135], human lung epithelial cells (BEAS-2B) [136,143,145], and primary mouse tracheal and human bronchial epithelial cells [139]

Cairns LV,Mills KI,Bezerra DP

Exogenous factors, including various pollutants, could further increase extracellular GSSG, perhaps limiting the export of GSSG against a concentration gradient

2013b) we also observed a twofold increase in ethanol titres for GSH1 compared to the control strain

The study led by Dr Vishnu Shankar, and including well-known researcher Professor Ron Davis within the team, explored bioenergetics (how cells produce and manage energy) in people with ME/CFS and long COVID, focusing on oxidative stress