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10.1016/j.bbrc.2025.152519 140 ZhangY.WangS.ChenX.WangZ.WangX.ZhouQ.et al (2022)

Its insulin-like effects improve glucose metabolism, potentially aiding in conditions like metabolic syndrome

Pharmacokinetic Obstacles: The widespread clinical adoption of FOXO4-DRI is hindered by typical peptide-based limitations: rapid enzymatic degradation, low membrane permeability, and the requirement for injectable administration (PNAS, 2026)