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LPS triggers inflammatory pathways in cardiomyocytes, leading to oxidative stress and apoptosis, which ultimately result in cardiac damage (171)

Generally, ceramides are involved in pro-survival autophagy, while PUFAs are involved in pro-death autophagy

doi: 10.3892/ijo.2024.5702 9

The animal foundation Beneath the two human studies sits the preclinical work

(91) demonstrated that disrupting mitochondrial activity in cultured MIO-M1 human Mller cells results in decreased basal ATP turnover and maximal respiration