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per-peptide content is reported on the certificate of analysis

Abbreviations DOX: Doxorubicin BC: Breast cancer ASMR: Age-standardized mortality rate ROS: Reactive oxygen species HFS: Hand-foot syndrome ADRs: Adverse drug reactions RORs: Reporting odds ratios PPE: Palmar-plantar erythrodysesthesia TRIM21: Tripartite motif-containing protein 21 LAD: Left anterior descending MEFs: Mouse embryonic fibroblasts Hyd: Hydralazine DIS: Disulfiram Nic: Niclosamide PCT: Paclitaxel DCT: Docetaxel LBPs: Lycium barbarum Polysaccharide QU: Quercetin PEFSO: Phenolic extract from flaxseed oil NPs: Nanoparticles MSG: Memecylon sisparense gamble leaves PNPs: Polymeric nanoparticles SNPs: Silver nanoparticles GN: Goldnanorods LCN: Lipid-core nanocapsules TNBC: Triple-negative breast cancer qRT-PCR: Quantitative real-time Polymerase chain reaction FRs: Folate receptors PPC: PEG-protamine complex PDI: Polydispersity index FTIR: Fourier transform infrared ROP: Ring opening polymerization HA: Hyaluronic acid SL-pH-HA: Stealth HA-targeted pH-sensitive liposomes SLNs: Solid lipid nanoparticles RGD: Arginine-glycine-aspartic EpCAM: Epithelial cellular adhesion molecule DTBH: 4,4-Dithiodibutyric acid APBA: 3-Aminophenyl boronic acid monohydrate LD: Low density HD: High density AMPK: Activated protein kinase MEFs: Mouse embryo fibroblasts HSA: Human serum albumin MDR: Multidrug resistance TPGS: D-alpha-tocopherol polyethylene glycol 1000 succinate ES: Estrone References Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P

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Statements Author contributions YZ and WY wrote the draft manuscript

This explains why the impairment of this protective immune system exacerbates APAP-ALI in Rag1-KO Batf3-KO mice