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In this approach, NO is generated from the donor compound 3-(2-hydroxy-1-methyl-ethyl-2-nitrosohydrazino)-N-methyl-1-propanamine, which is oxidized to NO2 by the target compound 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO)

Osbeck) against fructose-mediated protein oxidation and glycation

Slow transit time is one of the leading causes of SIBO (small intestinal bacterial overgrowth) which can cause impaired digestion, decreased nutrient absorption, and symptoms such as bloating, gas, diarrhea, and constipation

To this end, we developed an in-silico approach combining both unbiased identification of transcriptional signatures associated with oligodendroglial formation (i.e., transcriptomes) and knowledge-driven curation of transcriptional changes associated with oligodendrogenesis (i.e., OligoScore)

XiXLiJGuoSLiYXuFZhengMet al

10.1007/s11010-020-03965-7 96