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10.1038/mp.2009.60 199

quiz e19-20

The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function

By degrading ECM and releasing related angiogenic factors and inhibitors, they jointly regulate the formation of tumor blood vessels and play an important role in the process of lymphangiogenesis and lymphatic metastasis (82, 83)