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The cost measure should be able to be excluded regardless of when we become aware of the issue, when the significant change came into effect, or when the error first occurred

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Thus, in both Hartnup disease and cystinuria, oligopeptides are transported normally across the apical membrane and are hydrolyzed to amino acids in the cytosol, and the resulting neutral and cationic amino acids are readily transported out of the cell across the basolateral membrane

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