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Sep Purif Technol 354:129402

Re-expressing cell lines of HMOX2 WT, HW/GW mutant, or K68R mutant were analyzed by immunofluorescence with anti-HA, anti-Calnexin, and anti-Tom20 antibodies to visualize the localization of HMOX2, ER, and mitochondria, respectively

Reactive oxygen species (ROS) production in normal cells, but especially in tumor cells, which have increased oxygen demand and utilization, is countered by generating an antioxidant defense state