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Description

Diabetes promotes raised mitochondrial damage and ROS production to retinal microvessels, leading to corresponding inflammation and oxidative stress which induces DR

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The inhibition of CDC25 prevents the removal of inhibitory phosphates by CDK1 (Tyr15), thereby preventing its activation and entry into mitosis [139]

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Several studies have shown that glutathione related enzymes like GSH S-transferase (GST) and GSSG reductase isoforms are not uniformly distributed in nuclei and cytoplasm [15]

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Retrograde degeneration of neurite membrane structural integrity of nerve growth cones following in vitro exposure to mercury

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In addition, both Sev and ketamine led to the upregulation of RASD1, which can form a ternary complex with DMT1 and PAP7, thereby enhancing the capability of NMDARs to activate DMT1 for iron uptake (White et al., 2016), causing iron-induced cellular damage

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Singh A, Dees S, Grewal IS

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