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doi: 10.1371/journal.pone.0196921 90 YangMChenXHuXLiHHuangHFangYet al

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1 Despite the availability of multiple treatments, a substantial proportion of patients either fail to achieve remission, particularly in cases of treatment-resistant depression (TRD) and late-life depression

Furthermore, research indicates that trans- 3-indoleacrylic acid (IDA), a tryptophan metabolite originating from anaerobic peptostreptococcus , serves as an internal ligand for the aryl hydrocarbon receptor (AhR)