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Description

Methodology and mechanism

Most patients experience the first effects, like improved sleep, within 1 to 2 weeks

101 Phosphorylation of fumarate hydratase (FH) by p38 in response to TGF- signaling leads to its binding to the transcription factor CSL/p53 complex on the p21 promoter, which inhibits histone H3K36 demethylation, enhances p21 transcription, and induces cell growth arrest

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Color figures are included in the HTML version of this manuscript Additional information Edited by A Finazzi-Agro Supplementary Information accompanies the paper on Cell Death and Differentiation website ( Supplementary information Rights and permissions About this article Cite this article Franco, R., Cidlowski, J