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287 Consequently, the administration of 5-LOX or ALOX5AP inhibitors has been shown to alleviate lipid accumulation in adipocytes and adipose tissue in mice

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One of these enzymes, HNMT, needs SAM to do its job.2 So, for HNMT to break down histamine properly, its important that the MTHFR enzyme is working well to support this process

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