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Interestingly, alterations in lipid composition were observed in the raptor mutant group with total levels of cholesterol, ceramide, sphingomyelin, and glycosylceramide (critical component of myelinsee Section Reactive Oxygen Species) severely reduced in the whole spinal cord (Lebrun-Julien et al., Exogenous Modulators of OL Metabolism: From Drugs to Dietary Therapies Donepezil Promotes OL Differentiation and Increases Brain Glucose Metabolism The ability to exogenously regulate oligodendroglial metabolism has implications for a host of neurodegenerative diseases

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In addition, mRNA levels of pro-inflammatory genes, such as Ccl2 , iNOS , TNF, and IL-1 , were markedly downregulated in eWAT of HFD-fed Ssu72 aKO mice, with a declining trend of IL-6 (Fig

4 BednarekP.Pislewska-BednarekM.SvatosA.SchneiderB.DoubskyJ.MansurovaM.et al (2009)