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The fundamental difference is bioavailability : oral supplements must survive digestion, and absorption rates vary significantly

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48, 49 However, claudin-2 also serves other diverse functions including paracellular passage of cations (including sodium and calcium), cell proliferation and autophagy, and loss of claudin-2 along with claudin-15, yet another TJ protein implicated in paracellular Na + passage, results in premature death because of malnourishment in mice

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