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On his podcast, Andrew Huberman, MD, professor of neurobiology and ophthalmology at Stanford Universitys school of medicine, shared a potential, and slightly gory, origin story for BPC-157

Concomitant use with aspirin, other NSAIDs, probenecid, or pentoxifylline heightens gastrointestinal and bleeding toxicity and represents an absolute or relative contraindication

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Binge drinking degrades both the ability to fall asleep and to stay asleep in ways that compound over time

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What that looks like in practice: some people notice shifts in energy and how their body composition responds before the scale moves much, since the goal is metabolic, not just water weight