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Since the clock components of the liver were not altered, the authors speculated that the tumor may not function as a classical zeitgeber, but rather that it acts on the liver by rewiring circadian metabolic control, thereby dictating the pathophysiological dimension of a distal tissue 128

Diagnosis For patients presenting with clinical symptoms of vitamin B12 deficiency, current guidelines recommend testing serum vitamin B12 levels alongside a full blood count and folate levels[2]

doi: 10.1038/nature21711 205 MengJLuZLiuHZhangLZhangSChenYet al

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Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid

Other researchers also reported an increase in F2-IsoPs concentrations in the blood serum (78) and exhaled breath condensate of asthma patients (86)