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2020 Jan;39(1):110-122

It promotes angiogenesis and reduces inflammation, creating the conditions necessary for healing to begin

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Researchers from the University of Oklahoma recruited 51 untrained male volunteers for a double-blind placebo-controlled study [7] and randomly divided them into four groups: Placebo: received 34 grams of dextrose Creatine monohydrate: received 5.25 grams of creatine plus 34 grams of dextrose Beta-alanine: received 1.6 grams of beta-alanine plus 34 grams of dextrose Beta-alanine plus creatine: received 5.25 grams of creatine, 1.6 grams of beta-alanine, and 34 grams of dextrose [7] The volunteers consumed their assigned supplement four times per day for the first six days, then two times per day for the remainder of the study

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Mitochondrial-mediated ROS cause oxidative damage to cellular structures, particularly mitochondrial DNA, somatic mutations, genome instability, inactivation of tumor suppressor genes, alterations in metabolic and signaling pathways with simultaneous activation of compensatory antioxidant mechanisms, all of which contribute to cell transformation and thus promote various types of cancer [42]