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In endothelial cells, compensatory hyperinsulinemia can preferentially engage SHC/MAPK signaling, promoting expression of inflammatory mediators and adhesion molecules (ICAM-1, VCAM-1, E-selectin) while further suppressing PI3K/Akt activity [1012]

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Plant foods contain less, though small amounts are found in whole wheat, asparagus, and avocado

For intensity normalization, a pooled sample was generated by mixing equal aliquots of all digested samples prior to TMT labeling