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In chronic diseases associated with anemia of chronic disorders, erythropoietin may be helpful in averting or reducing transfusions of PRBCs (Maakaron & Besa, 2021)

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Analgesic Effect: Cold slows nerve signals, easing discomfort and soreness

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Superimposing a tonic pharmacological brake on top of this feedback system creates competing signals, and it would be unsurprising if intestinal feedback partially normalized emptying over time even while the drug is present