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discovered in mice that dapagliflozin can reduce renal fibrosis by suppressing the abnormal expression of collagen and amino acid transport proteins via mTORC1 inhibition [103]

Moreover, GSTP1 is associated with the MAPK pathway and TNF receptor-associated factor 2 (TRAF2) [31] to participate in the cell apoptosis, stress stimuli, cell differentiation and proliferation