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The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer

5-FU selectively kills cancer cells by increasing reactive oxygen species (ROS) to cytotoxic levels

Neuron 105, 776798

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IGF-1R and its downstream AKT/mTOR cascade stabilize hedgehog-induced transcription effector Gli2 protein, thereby enhancing a hedgehog-mediated effect on osteoblast differentiation (Shi et al., 2015)

On the other hand, spermatophores of the cuttlefish Ascarosepion apama maintained in filtered seawater at 4 C showed spermatozoa motility after two months (Naud and Havenhand 2006), thus, refrigeration is an alternative method to preserve spermatozoa in the medium term