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M., & Pincus, S

This appears to be dose-dependent, with moderate doses enhancing sleep quality while excessive doses may paradoxically impair deep sleep architecture

For example, the proteozome inhibitor Bortezimib is effective at blocking disease in the NZB/W model in both the profilactic and therapeuctic model with reductions in autoantibody production, kidney damage, and improvements in survival {Nature Medicine 14, 748 - 755 (2008))