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The increased teratogenic risk from valproic acid in women with epilepsy is expected to be reflected in an increased risk in other indications (e.g., migraine or bipolar disorder)

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For example, not fully clarified are functions of pleiotropic compounds formed through TRP-KYN pathway, such as kynurenine (KYN), anthranilic acid (ANA), kynurenic acid (KYNA), and quinolinic acid (QA), capable modulate brain and immune system, and which play a role in the pathogenesis of a wide range of illnesses, including cancer, liver cirrhosis, and neurodegenerative and psychiatric diseases, such as dementia, Alzheimers disease, Parkinsons disease, multiple sclerosis, and schizophrenia [2,3]

Although there were no statistically significant differences between the treatment groups for adverse events, numbers of subjects reporting adverse events, serious adverse events, treatment-related adverse events, and severe adverse events were all greater in the treatment group (Table 12)

Malaguarnera, M., Risino, C., Cammalleri, L., Malaguarnera, L., Astuto, M., Vecchio, I., and Rampello, L