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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

Shewale JB, Mitchell KG, Nelson DB, Conley AP, Rice DC, Antonoff MB , Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Mehran RJ, Vaporciyan AA, Weissferdt A, Sepesi B

Additionally, a multi-center study found that approximately 80% of their newly diagnosed patients with PD who survived had dementia at a 20 year follow up (Hely et al., 2008)

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Thase ME, Entsuah AR, Rudolph RL

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