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Protective effect of ibuprofen-coupled nanocarriers on the barrier integrity of cytokine treated human BBB model The changes in the barrier integrity of human brain endothelial cells after CK treatment alone and in co-treatments with ibuprofen or ibuprofen-coupled nanocarriers were followed by real-time impedance measurements for 24 h (Fig

4.1.4 Secondary bile acids Bile acids are synthesized from cholesterol in the liver via oxidative pathways