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Specifically, animal studies show MPs can disrupt the -diversity of gut microbiota and decrease the Firmicutes-to-Bacteroidetes (F/B) ratio, resulting in an increased relative abundance of pathogenic bacteria in ICR mice (Wang et al., 2002), which are critical factors in the pathogenesis of neurodegenerative diseases

Up-regulating SreBP-1 expression raises the activities of fatty acid synthase and acetyl coenzyme A carboxylase, which stimulates the production of fatty acids and cholesterol and causes abnormal lipid buildup in renal tubular cells[41]

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Concurrently, a decrease in gastric acid production coupled with an increase in mucus secretion elevates gastric pH

J Biol Chem 267:1522415228 Vartanyan LS, Gurevich S, Kozachenko AI, Nagler LG, Lozovskaya EL, Burlakova EB (2000) Changes in superoxide production rate and in superoxide dismutase and glutathione peroxidase activities in subcellular organelles in mouse liver under exposure to low doses of low-intensity radiation

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