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Changes in Appetite: A few individuals notice increased or decreased appetite, likely linked to gastrointestinal modulation

As more and more high dose oral B12 is administered the situation gradually gets worse and worse, because now much of the HC secreted in saliva (Collins etal 1999) already has inactive B12 bound to it, and so this HC-B12 complex can no longer protect incoming B12 from acid hydrolysis

They are meant to help people with B12 deficiency

Citations [1] Lau DCW, Erichsen L, Francisco AM, Satylganova A, le Roux CW, McGowan B, Pedersen SD, Pietilinen KH, Rubino D, Batterham RL

Get started *Outcomes based on peer-reviewed retrospective observational studies of Ivm patients published in Obesity Pillars (June 2025, March 2026)

Unlike oral supplements, these injections go straight into your bloodstream for faster, more noticeable effects