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These pathways are activated following the binding of IL-13 to its receptor and the phosphorylation and translocation of STAT-6 to the nucleus

Despite being expressed at significantly higher levels than endogenous LRP6, we found that bait expression is comparable to that of LRP6-GFP in stably transfected LRP5/6 DKO cells whose signaling activity is strictly Wnt-dependent (Supplementary Fig