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With the development of modern technology, a series of new avenues have been employed to improve efficiency ( Featuring simplicity, effectiveness, and long-term preventive capability, vaccines are undoubtedly a vital tool for controlling infectious diseases on a large scale and compensate for the deficiency of drug and surgical treatment to a large extent

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Peritoneal IL-16 can induce the release of cytokines, such as IL-6, TNF-, and IL-1, from peritoneal fluid mononuclear cells (PFMC)leading to inflammatory manifestations [140]