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Mechanisms, models and biomarkers in amyotrophic lateral sclerosis

The population of microorganisms will also vary along the GI, affected by numerous factors such as pH, host enzymes (proteases, lipase), redox potential, mucin secretion, peristaltic activity, and nutrient availability (Hao and Lee, 2004)

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Dysfunctional autophagy allows damaged proteins and organelles to accumulate, propagating the genome instability and promoting genome mutation and possibly carcinogenesis [14]