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EMBO Mol Med 15:EMMM202217052-

CagriSema is closest to potential approval among GLP-1/amylin combinations

2011;3:S7S19

They are intentionally developed through a framework that transforms alignment into measurable impact

Researchers raise doses in animals until roughly 50% die, giving a crude measure of acute lethality that does not translate directly to human safety but gives context for risk margins