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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

Recessive mutations in genes coding for enzymes of the kynurenine pathway namely kynureninase and 3-hydroxyanthranilic-acid 3,4-dioxygenase lead to combined vertebral, anal, cardiac, tracheo-esophageal, renal, and limb (VACTERL) congenital malformations (76)

Preconditioning with Maillard reaction products improves antioxidant defence leading to increased stress tolerance in cardiac cells

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Some of these trials may be conditioned by the short duration of butyrate administration, small sample size, lack of placebo control, and variability within the target population

C., Koshkin, V