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2 Materials and methods 2.1 Protein structures and evaluation The hMRP1 ( and hMRP7 ( structures were predicted using AlphaFold ( Evaluation of the AlphaFold predicted model protein structures was performed using pLDDT (predicted Local Distance Difference Test) (Sippl, 1993), ERRAT (Williams et al., 2018)) integrated within the SWISS-MODEL workspace (Waterhouse et al., 2018)

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The percentage of subjects receiving OCA 25 mg that achieved the primary endpoint was 23.8% among those with baseline GLP-1 RA use, 21.6% of those who added a GLP-1 RA, and 22.4% in the overall ITT population, compared to 4.3%, 7.5%, and 9.6% receiving placebo, respectively (Figure 1)

We tested this idea using genetic and pharmacological inhibition of TS activity

350 For example, aged HSCs exhibit a diminished capacity to adhere to stromal cells, which may perturb the interactions between stem cells and the hematopoietic niche, ultimately leading to alterations in the functionality of aging HSCs

Gastroenterology 2001