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These oxygen free radicals interact with iron ions to form highly reactive oxides, thereby initiating cellular ferroptosis ( Furthermore, specific test agents, including elastin and RSL3 [(1S,3R)-RSL3, an inhibitor of GPX4 that reduces GPX4 protein expression], as well as approved pharmaceuticals such as sorafenib, sulfasalazine, statins, and artemisinin, along with ionizing radiation and cytokines such as IFN and TGF1, have been demonstrated to induce ferroptosis ( Figure 2 )